CHOLINE ACETYLASE

Biological Significance of Choline Acetylase **

Studies on Choline Acetylase Iv. Effect of Citric Acid* by David Nachmansohn

Previous investigations have revealed that the formation of acetylcholine by the enzyme choline acetylase requires for maximum activity, in addition to the protein moiety, the following components: K+, Mg++, adenosine triphosphate (ATP), a coenzyme, cysteine, and eserine (l-5). The coenzyme, described simultaneously by Nachmansohn and Berman and Lipmann and Kaplan (5, 6), contains apparently pa...

Effects of Sex Steroids on the Choline Acetylase Activity in the Hypothalamus of Female Rats.

The central nervous system, especially the hypothalamus, exerts an influence on the gonadotropin secretion from the anterior pituitary, resulting in the stimulation of gonads. The sex steroids, in turn, react back on the central nervous system in order to adjust the anterior pituitary function for reproductive cycles (Harris, 1955a). As reported in the previous paper (Kobayashi et al., 1963), t...

Quantitative determination of choline acetylase, acetylcholine, and acetylcholinesterase in the developing rabbit cornea.

Components of the cholinergic nervous system, acetyl choline (ACh), choline acetyltransferase (ChAc), and acetylcholinesterase (AChE) have been measured quantitatively in the developing rabbit cornea. ACh was detected initially approximately 10 days after birth, and subsequently increased in a nonlinear fashion to attain adult levels approximately 50 days after birth. ChAc was found initially a...

Cholinergic enzymatic activity of cerebrospinal fluid of patients with various neurologic diseases.

The cerebrospinal fluid (CSF) of normal humans contains both true and pseudocholinesterases and choline acetyl transferase (choline acetylase) detectable by radiochemical assay. Elevations of total cholinesterase, pseudocholinesterase, and true cholinesterase occur in brain tumors, meningitis, Guillain-Barre disease, hydrocephalus, and brain abscess. However, the non-specificity and inconstancy...